On her deathbed, Aileen’s mother reveals a secret she has kept for eighteen years, and pleads with her daughter to fulfill a last wish. Torn by grief, Aileen leaves Dublin, the Fair City, and Dermot, the man she has grown to love. When she finally decides to return to Dermot, and the family she loves, will the secret she too is now hiding tear her and Dermot apart?

Young Jo Kingsley leaves war-torn Ireland for Paris, finding work in Chateau Colbert. Jean-Pierre, her employer's grandson, introduces her to Paris and womanly desires. Jo then travels to Prohibition American and falls in love with Mike Pasiński. Loneliness, loss and hardship follow during the Wall Street crash. Will the beautiful Jo let go of her demons and learn to love again?

Irish gypsy Tamara Redmond overhears her parents planning her wedding to the powerful and hated Jake Travis. Running away, stowing away on a ship lands her in prison. Released, she takes refuge in a travelling circus, falling in love with Kit Trevelyan. She's thrown out, accused of stealing. On the run from Travis, she risks losing Kit. When a truth is revealed, her life could change forever.

Twenty-year-old Sarah Nolan leaves her Dublin home, taking a job in Cork City with The Gazette, a move her parents strongly oppose. She soon befriends sixteen-year-old Lucy who's been left abandoned and pregnant. Dan Madden is a charming and flirtatious journalist who wins Sarah's heart, but he's engaged to Ruth. Sarah discovers some long-hidden secrets of her own. Will they destroy her future?

While struggling to survive the deaths of her husband and daughter, Oona Quinn meets charismatic Jack Walsh. His gentle and loving ways show Oona a bright future. Vinnie Kelly, her son's biological father, threatens to destroy the peace Oona is finding. Haunted by her past, Oona must fight for everything she holds dear and accept the new love she's found.